The Gulf of Urabá is a gulf on the northern coast of South America. It is part of the Caribbean Sea. It is a long narrow inlet in the coast of Colombia, close to the connection of the continent to the Isthmus of Panama. The town of Turbo lies at the southern end of the Gulf. The Atrato River flows into the Gulf of Uraba.
A study by Bio-Pacifico has suggested, as an alternative to building a 54-mile link across the Darien gap to complete the Pan-American Highway, that the Panama section of the highway be extended to the Caribbean coast and terminate at the Gulf of Urabá, then be connected by ferry to existing highways in Colombia.
The area surrounding the gulf comprises a geopolitical subregion of Colombia known as Urabá Antioquia.